Symbol
Name
ID

Ptpn2
protein tyrosine phosphatase, non-receptor type 2
MGI:97806

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

hematopoietic system phenotype

abnormal osteoclast differentiation

thymus atrophy

decreased thymocyte number

abnormal thymus involution

enlarged spleen

spleen hyperplasia

abnormal erythropoiesis

decreased immature B cell number

abnormal T cell differentiation

abnormal negative T cell selection

abnormal positive T cell selection

decreased double-positive T cell number

anemia

abnormal bone marrow cell morphology/development

abnormal bone marrow cell number

decreased bone marrow cell number

decreased erythroid progenitor cell number

decreased erythrocyte cell number

decreased hematocrit

increased hemoglobin content

increased mean corpuscular hemoglobin

abnormal B cell number

decreased mature B cell number

decreased B-1 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased mature B cell number

decreased B cell number

increased B cell number

increased pre-B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

increased macrophage cell number

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

abnormal osteoclast physiology

Availability

Mouse Genotype

Ptpn2^tm1Mtr/Ptpn2^tm1Mtr

Ptpn2^tm2.1Ttig/Ptpn2^tm2.1Ttig

Ptpn2^{tm1a(EUCOMM)Wtsi}/Ptpn2⁺

Ptpn2^tm1.1Kry/Ptpn2^tm1.1Kry
Tg(Col1a1-cre)1Kry/0 (conditional)

Ptpn2^tm1.1Ttig/Ptpn2^tm1.1Ttig
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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